The metabolism and antiketogenic effects of sorbitol. Sorbitol dehydrogenase

The antiketogenic action of sorbitol.

Sorbitol dehydrogenase is a cytosolic protein required for sorbitol metabolism in Arabidopsis thaliana.

Sorbitol is converted to fructose in Rosaceae species by SORBITOL DEHYDROGENASE (SDH, EC 1.1.1.14), especially in sink organs. SDH has also been found in non-Rosaceae species and here we show that the protein encoded by At5g51970 in Arabidopsis thaliana (L.) Heynh. possesses the molecular characteristics of an SDH. Using a green fluorescent protein-tagged version and anti-SDH antisera, we deter...

Metabolism of 59Fe-sorbitol complex in man.

LUMBAR SPINE DENSITOMETRY BI&TISN _ ~~~~~~~~~~~~MEDICAL JOURNAL which in due course will enable us to define the distribution in statistical-terms. In the meantime an R.V.D. ratio of less than unity indicates a vertebral density less than our standard. We are not yet prepared to define the reduction in bone density which justifies the use of the term " osteoporosis," but consider it axiomatic t...

Detection and characterization of sorbitol dehydrogenase from apple callus tissue.

Sorbitol dehydrogenase (l-iditol:NAD(+) oxidoreductase, EC 1.1.1.14) has been detected and characterized from apple (Malus domestica cv. Granny Smith) mesocarp tissue cultures. The enzyme oxidized sorbitol, xylitol, l-arabitol, ribitol, and l-threitol in the presence of NAD. NADP could not replace NAD. Mannitol was slightly oxidized (8% of sorbitol). Other polyols that did not serve as substrat...

Sorbitol Dehydrogenase Activity in Diabetes Mellitus and Cataract Patients

Accumulation of sorbitol in the pathogenesis of cataract in susceptible subjects has long been an issue. Sorbitol dehydrogenase (SDH) activity in 25 diabetes mellitus (DM) patients and 15 patients having cataract was investigated using 10 subjects without diabetes or cataract as the control. Results of fasting plasma glucose assay done on the DM patients showed a mean range of 64 – 144mg/dl in ...